Treatments Explained3 min read

Rejuran I vs Rejuran S: Which One to Choose?

Rejuran i vs rejuran s

“If you are excited to understand more about the Rejuran i vs Rejuran S, please consult our experienced doctors at Kaiteki Clinic. We will create a personalized treatment plan tailored to your needs! “

Introduction

When it comes to aesthetics, one-size-fits-all is a tired myth best left behind. Today’s beauty seekers are savvier, asking the right questions and expecting tailored solutions—and rightly so.

Introducing Rejuran I and Rejuran S, two treatments that may come from the same lineage but couldn’t be more different in purpose, texture, and technique.

Knowing which one belongs in your skincare script is the difference between “good enough” and just right.

What Exactly Is Rejuran?

Before we put them head-to-head, let’s rewind a little. Rejuran is a skin-healing injectable treatment made with polynucleotides (PN) derived from salmon DNA. Why salmon? Its DNA shares a remarkably similar structure with humans, making it well-tolerated and highly effective in restoring skin health.

Rejuran works by stimulating collagen production, reducing inflammation, and strengthening the skin barrier. The result? Smoother, more youthful skin from the inside out.

But not all Rejuran formulas are created equal.

Rejuran I: The Under-Eye Solution

Think of Rejuran I as the precision artist of the Rejuran family. It’s crafted specifically for the fragile under-eye zone, where the skin is thinner, more prone to creasing, and notoriously tricky to treat.

  • Low viscosity means it’s feather-light—ideal for fine lines and dehydration around the eyes.

  • It helps reduce dark circles, crow’s feet, and under-eye hollows without causing puffiness.

  • Because it spreads smoothly, there’s minimal risk of lumpiness—a common complaint with generic fillers.

Patients who want a fresher, more awake look without the heaviness of traditional fillers often turn to Rejuran I for that touch of refinement.

Rejuran S: The Scar Solution

On the flip side, Rejuran S comes in like a sculptor—designed to reshape and refine where the skin’s texture has lost its smoothness due to trauma, usually in the form of acne scars.

  • This version has a higher viscosity and is injected more deeply.

  • It works by remodelling fibrotic scar tissue and stimulating collagen from within.

  • Rejuran S is especially effective on atrophic acne scars—those sunken, uneven patches that just won’t budge with surface-level treatments.

For anyone waging a long-term war against stubborn acne scars, Rejuran S is a quiet powerhouse with results that build session by session.

Key Differences

FeatureRejuran IRejuran S
Target AreaUnder-eyes, fine linesAcne scars, textured skin
ViscosityLow – light and fluidHigh – thick and concentrated
Injection DepthSuperficial dermisDeep dermis
Primary BenefitHydration, brightening, wrinkle-softeningScar remodelling, collagen stimulation
Risk of PuffinessMinimalModerate (not used under eyes)
Ideal ForTired eyes, early signs of agingPost-acne scarring, uneven texture

Which One Should You Choose?

The short answer: it depends on your skin’s story.

If you’re waking up to tired, shadowy under-eyes or creeping crow’s feet, Rejuran I is your ticket to looking quietly refreshed. But if the mirror reflects the aftermath of old breakouts—textural acne scars that mkakeup just can’t hide—Rejuran S delivers a slow but steady comeback.

Still unsure? Your best move is a chat with a trained aesthetic doctor who can assess your skin’s texture, thickness, and responsiveness to treatment. At Kaiteki Clinic, we approach each face as a canvas—unique, deserving of a bespoke plan, and never treated with cookie-cutter fixes.

Book a free consultation

A doctor will assess your skin and tell you honestly whether this is the right option for you, including when it is not.

About the author

Dr William Yap, MD, LCP Board Certified, MAC, aesthetic doctor at Kaiteki Skin Aesthetic Clinic

Dr William Yap

Partner, Aesthetic Physician

MD, LCP Board Certified, MAC · MMC 68812

Dr William Yap obtained his Medical Degree (MD) from University of Gahjah Mada. After completing his compulsory house officer training, he continued his 6 years journey in government hospital as medical officer. He has been rotating in different subdepartment including dermatology, infectious disease, cardiology, etc to enhance his skills and knowledge.

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Written by
Dr William Yap, MMC 68812
Published
23 April 2025
Topics
Treatment vs Treatment, Acne, Acne Scars, Skin Boosters
Last reviewed
29 April 2025

This page is general information about aesthetic treatments and is not medical advice. Treatments carry risks that are explained during consultation, and individual results vary. A doctor will assess whether a treatment is suitable for you before it is carried out.

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