Treatments Explained2 min read
Skinvive vs Rejuran: A Clear Comparison of Benefits and Uses

“If you are excited to understand more about Skinvive and Rejuran, please consult our experienced doctors at Kaiteki Clinic. We will create a personalized treatment plan tailored to your needs! “
Introduction
The purpose of comparing Skinvive and Rejuran is to support better decision-making by helping patients and practitioners understand the key differences between these two skin treatments based on their goals, skin concerns, mechanism of action, and desired outcomes.
Overview of Skinvive and Rejuran
What is Skinvive?
Skinvive is an injectable skin booster made by Juvederm (Allergan Aesthetics) using hyaluronic acid. It is designed to improve skin hydration, smooth texture, and give a subtle glow. Suitable for dull, dehydrated, tired-looking skin, early signs of aging, and those wanting a natural glow.
What is Rejuran?
Rejuran is a skin-rejuvenating injectable treatment using polynucleotides (PN) from salmon DNA to promote cell regeneration, healing, and anti-aging effects. Ideal for sensitive/inflamed skin needing repair, aging skin, and acne scars.
Primary Benefits:
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Enhances skin elasticity and texture
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Stimulates collagen production
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Reduces fine lines, wrinkles, and acne scars
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Strengthens skin barrier
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Improves tone and radiance
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Anti-inflammatory and healing properties
Key Differences
| Feature | Skinvive (by Juvederm) | Rejuran (Rejuran Healer) |
|---|---|---|
| Main Ingredient | Hyaluronic Acid (HA) | Polynucleotides (PN) from salmon DNA |
| Mechanism of Action | Provide moisture and improves skin smoothness from within | Stimulates skin regeneration, repair and healing, and collagen production |
| Primary Benefits | Skin hydration, glow | Skin repair, anti-aging, scar healing |
| Treatment Area | Cheeks (approved), off-label for other facial areas | Face, neck, under eyes, hands (versatile) |
| Longevity | ~6 months | 6–12 months (with maintenance) |
| Downtime | Minimal (redness/swelling may last 1–2 days) | Minimal (small bumps, swelling, or redness for 2–3 days) |
Treatment Process and Experience
Application Techniques
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Skinvive: Injected as microdroplets more superficially for hydration
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Rejuran: Injected with microneedles deeper for skin repair
Can be combined in one session.
Downtime and Recovery
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Skinvive: Mild redness/swelling, resolves in 24–48 hours
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Rejuran: Redness, swelling, bumps up to 2–3 days Most patients resume activities same or next day.
Patient Comfort
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Skinvive: Contains lidocaine, minimal discomfort
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Rejuran: Requires topical numbing cream; more stinging reported during injection
Efficacy and Visible Results
Expected Outcomes
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Skinvive: Hydration, smoothness, glow
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Rejuran: Collagen regeneration, healing, scar improvement
Timeline for Improvements
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Skinvive: Visible results after 1 session
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Rejuran: Gradual improvement over 2–4 weeks, usually needs 3–4 sessions
Longevity of Results
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Skinvive: Lasts while hydration is maintained
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Rejuran: Lasts 6–12 months with maintenance
Ideal Candidates and Indications
Suitability for Skin Types
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Skinvive: All skin types (not for pregnant/breastfeeding)
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Rejuran: Damaged/sensitive skin, acne scars, aging skin
Targeted Skin Concerns
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Skinvive: Dehydration, dull skin, texture
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Rejuran: Repair, aging, scars
Age Considerations
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Skinvive: Adults 18+ seeking hydration/glow
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Rejuran: Adults in late 20s+ seeking repair/anti-aging
Safety, Side Effects, and Risks
Common Side Effects
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Skinvive: Mild swelling, redness
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Rejuran: Redness, swelling, bumps, bruising, itching
Rare Complications
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Infection: if hygiene is poor
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Lumps: from poor injection technique
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Allergic reaction: rare; lower risk in Rejuran due to DNA compatibility
Precautions and Aftercare
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Disclose allergies, conditions, medications before injection
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Avoid exercise, alcohol, sauna, sun for 24–48 hours
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Avoid makeup, harsh products for 24 hours post-treatment
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Use gentle skincare, stay hydrated
Free Consultation with Kaiteki Clinic
Still unsure which treatment suits you? Get a free consultation at Kaiteki Clinic — personalized assessment based on your skin type, concerns, and goals for clearer, healthier skin.
Book a free consultation
A doctor will assess your skin and tell you honestly whether this is the right option for you, including when it is not.
About the author

Dr Jacqueline Tan
Aesthetic Physician
MBBS, LCP Board Certified, MSc (UCSI) · MMC 83965
Dr. Jacqueline Tan graduated from IMU with a Bachelor of Medicine & Surgery (MBBS). She started her career as a doctor and has completed her 2 years compulsory service as a house officer in government hospital. She continued her medical journey as a medical officer in the Emergency Department to enhance her skill and experience in resuscitation. Being involved in emergency cases, her nature is being calm, empathic and determined.
View full profile- Written by
- Dr Jacqueline Tan, MMC 83965
- Published
- 30 July 2025
- Topics
- Treatment vs Treatment, Skin Boosters, Skin rejuvenation
- Last reviewed
- 4 August 2025
This page is general information about aesthetic treatments and is not medical advice. Treatments carry risks that are explained during consultation, and individual results vary. A doctor will assess whether a treatment is suitable for you before it is carried out.



