Plinest/Newest

Plinest and Newest are injectable polynucleotide products made by Mastelli, an Italian pharmaceutical company. Polynucleotides are chains of purified DNA fragments, and Mastelli's are derived from trout, a point of difference worth knowing, since the better-known Korean polynucleotide products are salmon-derived. The manufacturer's trademark for its extraction and purification process is PN-HPT™, which stands for Polynucleotides Highly Purified Technology, and it presents the purity grade of the polynucleotide chains as the defining feature of the range.

The two names are not interchangeable products. Plinest is the polynucleotide formulation on its own; Newest is described by the manufacturer as combining PN-HPT with hyaluronic acid and mannitol, so a hydration component and an antioxidant component sit alongside the polynucleotides. The range also includes presentations intended for particular areas such as the eye region. Which product, if any in this category, suits you, and the quantity and technique used, is decided by the treating doctor after an in-person assessment.

Polynucleotides are a different material from the hyaluronic acid used in hydration boosters and from the poly-lactic acid used in collagen-stimulating boosters. Mastelli describes PN-HPT as producing long polynucleotide chains that form a hydrating gel-like matrix in the skin and support fibroblast activity, the cells that produce the skin's structural proteins. In Newest, the added hyaluronic acid contributes water-binding, while the manufacturer associates mannitol with antioxidant, free-radical-scavenging properties.

The intention is a change in skin quality, elasticity and resilience rather than in contour or volume. Plinest and Newest are commonly considered where the concern is the quality and elasticity of the skin itself rather than lost volume. Neither is suitable for everyone, and a consultation determines whether either is appropriate for you.

Concerns the range is typically directed at include:

Delivery is by a series of small injections distributed across the treatment area. A topical anaesthetic is commonly applied beforehand for comfort. The formulation, the quantity, the distribution and the depth are all chosen by the treating doctor for your skin, your concern and the area involved. Changes develop gradually over weeks and vary between individuals.

The range is used beyond the face: the eye area, the neck and the hands are all areas it is considered for, and the Mastelli range includes presentations intended for particular areas such as the eye region. Which area, if any, is appropriate for you is decided at an in-person consultation.

Mastelli's polynucleotides are fish-derived, so you must declare any fish or seafood allergy before treatment. If Newest is being considered, a known hypersensitivity to hyaluronic acid or mannitol matters too.

The range is aimed at adults whose priority is skin quality rather than contour. Because it works through injected material rather than light or heat, skin tone is not a limiting factor in the way it can be with laser treatment, and it is used across a range of skin tones, though that does not make it appropriate for everyone.

It may not be suitable during pregnancy or breastfeeding, where there is active infection, an acne flare or inflammation at the intended site, if you have a bleeding disorder or take blood-thinning medication, or alongside certain autoimmune conditions. Please share your full medical history, allergies, medications and previous injectable treatments at consultation so your doctor can advise safely.

These products are used within Kaiteki's skin-booster treatment, so a visit begins with a doctor consultation and skin assessment that includes whether a polynucleotide product is the right category for you, and if so which formulation. If it is appropriate, the skin is cleansed and a topical anaesthetic is usually applied and left to take effect, which accounts for much of the appointment time.

The doctor then places a series of small injections across the assessed area. Including preparation and numbing, a visit commonly runs from around half an hour upwards depending on the area. A course of several sessions spaced a few weeks apart is often described for polynucleotide treatment, but the number and the spacing are set by your doctor for your skin and response rather than fixed in advance, and should not be read as a promised schedule.

Downtime is usually short but visible for a period. Small raised bumps at each injection point are expected and commonly settle within a day or two as the product disperses, though this varies between individuals and by area. Redness, mild swelling and pinpoint bruising can also occur.

Gentle skincare and consistent sun protection are advised afterwards, and your doctor will tell you when to resume active skincare, makeup, exercise and heat exposure. Follow the aftercare they give you for your skin rather than generic advice.

As with any injectable procedure, Plinest and Newest carry risks, which are explained during consultation. Temporary effects can include injection-site bumps, swelling, redness, bruising and tenderness. Less common effects include infection, prolonged swelling, nodules or hypersensitivity reactions, and vascular complications are rare but recognised with any facial injection. Serious effects are uncommon when the product is appropriately selected and administered by a trained doctor.