Rejuran

Rejuran is a range of injectable polynucleotide (PN) products made by Pharma Research, a South Korean company. Polynucleotides are chains of purified DNA fragments; in Rejuran's case they are sourced from salmon, chosen by the manufacturer for its biocompatibility. This places Rejuran in a different skin-booster category from hyaluronic acid boosters: an HA booster is chosen mainly to hold water in the skin, whereas a polynucleotide product is directed at the skin's own repair and barrier environment.

The range is not a single product. Alongside the original Rejuran, the manufacturer produces variants formulated for different purposes, including a scar-directed version (Rejuran S), an eye-area version, and a hybrid that combines polynucleotides with hyaluronic acid (Rejuran HB). Which variant is appropriate, whether Rejuran is the right category for you at all, and the amount and technique used are decisions the treating doctor makes after an in-person assessment.

The manufacturer describes Rejuran's polynucleotides as purified, fragmented DNA chains that form a soft gel-like matrix once placed in the skin and that support fibroblast activity, the cells responsible for producing the skin's structural proteins. The hybrid variant adds hyaluronic acid so that a hydration component sits alongside the polynucleotide component.

Delivery is by a series of small injections spread across the treatment area rather than a single placement, and a topical anaesthetic is commonly applied beforehand for comfort. The variant, the quantity, the distribution and the depth are all selected by the treating doctor for your skin and concern. Changes develop gradually over weeks and vary between individuals. Nothing here is a promised outcome.

No. The manufacturer describes Rejuran as working with the skin's own repair processes rather than adding volume, which is why the intended change is in skin quality, texture and resilience rather than in shape.

Rejuran is commonly considered where the concern is skin quality and resilience rather than volume. It is not suitable for everyone, and a consultation determines whether it is appropriate for you. Concerns it is typically directed at include:

Both are polynucleotide skin boosters, but they come from different manufacturers and different sources: Rejuran's polynucleotides are salmon-derived and made by Pharma Research in Korea, while Mastelli's Plinest and Newest are trout-derived and use its PN-HPT purification technology.

Their formulations and available variants also differ. The Rejuran range includes a scar-directed version, an eye-area version and a hybrid that combines polynucleotides with hyaluronic acid; Mastelli's Newest combines PN-HPT with hyaluronic acid and mannitol. Neither is presented here as superior: which one a doctor selects depends on your assessment, and that decision is theirs to make in person.

Because the polynucleotides are salmon-derived, you must tell your doctor if you have any fish or seafood allergy. Your doctor will weigh that history and may advise against it or consider a different category of product.

Rejuran is aimed at adults whose priority is skin quality rather than contour, and because it does not rely on light or heat, skin tone is not a limiting factor in the way it can be with laser treatment. It is used across a range of skin tones, though that does not make it appropriate for everyone.

It may not be suitable during pregnancy or breastfeeding, where there is active infection, an acne flare or inflammation at the intended site, if you have a tendency to keloid or hypertrophic scarring, if you have a bleeding disorder or take blood-thinning medication, or alongside certain autoimmune conditions. Please share your full medical history, allergies, medications and previous injectable treatments at consultation so your doctor can advise safely.

Rejuran is used within Kaiteki's skin-booster treatment, and a session begins with a doctor consultation and skin assessment, including which variant, if any, suits your concern. If it is appropriate, the skin is cleansed and a topical anaesthetic is usually applied and left to take effect, which accounts for much of the appointment time.

The doctor then places a series of small injections across the assessed area. Including preparation and numbing, a visit commonly runs from around half an hour to somewhat longer depending on the area. A course of several sessions spaced a few weeks apart is often described for polynucleotide treatment, but the number and spacing is set by your doctor for your skin rather than fixed in advance, and should not be treated as a guaranteed schedule.

Downtime is usually short but genuinely visible for a period. Small raised bumps at each injection point are expected and commonly settle over roughly one to two days as the product disperses, though this varies. Redness, mild swelling and pinpoint bruising can also occur.

Gentle skincare and diligent sun protection are advised afterwards, and your doctor will tell you when to resume actives, makeup, exercise and heat exposure. Follow their instructions for your skin rather than generic advice.

As with any injectable procedure, Rejuran carries risks, which are explained during consultation. Temporary effects can include injection-site bumps, swelling, redness, bruising and tenderness. Less common effects include infection, prolonged swelling, nodules or hypersensitivity reactions, and vascular complications are rare but recognised with any facial injection. Serious effects are uncommon when the product is appropriately selected and administered by a trained doctor.